Liverpool finished 2016 second in the Premier League with a 1-0 victory over third-placed Manchester City on Saturday.
Here are six who could make the biggest impact in this season's English Premier League.
Premier League leaders Manchester City won their derby with United 3-1, while Liverpool kept pace with a home win over Fulham.
English newspapers had linked Sanchez with a move to Pep Guardiola's side in exchange for England forward Raheem Sterling.
With his calm guidance, Ancelotti gave Vinicius the confidence he needed to flourish.
European champions Liverpool were beaten 0-2 by Fulham in the English Premier League.
A preview of the line-up action in the English Premier League.
Scotland's Clarke names uncapped trio in Euro squad.
Jose Mourinho's agent has dismissed as 'absolutely ridiculous and totally absurd' a report that the Portuguese wrote a 'love letter' to Manchester United to trumpet his case to be their next manager.
Headers by Romelu Lukaku and Nemanja Matic earned Manchester United an unconvincing 2-0 victory over Brighton and Hove Albion in a low-key FA Cup quarter-final played in freezing conditions on Saturday.
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Liverpool are champions and Norwich City, the side whom they beat on Aug. 9 to launch their title charge, are down and Manchester City are distant runners-up. After that everything is up for grabs.
Manchester United manager David Moyes has said that he demands better from the club's players as the side slumped to an embarrassing defeat to local rivals Manchester City and unleashed anger at his team.
Yaya Toure's deflected equaliser gave Manchester City a 1-1 draw at Stoke City on Saturday to reclaim top spot in the Premier League but two more away dropped points handed the advantage to Manchester United in the title race.
Manchester United's Bruno Fernandes fired home a late penalty to rescue a point for the visitors in a lively 1-1 draw at Tottenham Hotspur in the Premier League on Friday.
Barcelona stand between Chelsea and a second successive appearance in an all-English Champions League final. Manchester United, who beat Chelsea on penalties in last year's final in Moscow, take a 1-0 advantage to Arsenal on Tuesday in the other semi-final.
Hazard extra-time goal sends 10-man Real Madrid through to Copa del Rey final.
Reading snatched a 1-1 draw at Manchester United while Chelsea trounced Norwich City 4-0 to reach the FA Cup quarter-finals.
A 'winning culture' may be one of the most over used terms in modern football but Real Madrid and Carlo Ancelotti proved on Saturday, at Liverpool's expense, that there truly is meaning and value in the concept.
United are 16th in the standings with a game in hand heading into the international break.
Manchester United's injured players can utilise the international break to regain full fitness while key squad members can get much-needed rest, manager Jose Mourinho has said.
Manchester United celebrated 20 years under Alex Ferguson's command with an emphatic 3-0 victory over Portsmouth.
Manchester City manager Roberto Mancini used every attacking weapon at his disposal on Saturday and was left frustrated after the various combinations failed to get the better of Everton.
Manchester United took advantage of Chelsea's inactivity on Saturday to reclaim top spot in the Premier League, the 35-year-old Paul Scholes clinching a 1-0 victory at struggling Wolverhampton Wanderers. The champions, without injured striker Wayne Rooney, laboured at Molineux but Scholes pounced for his 100th league goal after 73 minutes to put United on 63 points, two ahead of Chelsea who are in FA Cup action against Stoke City on Sunday.
Arsenal and arch rivals Manchester United fought out a tense 0-0 draw on Tuesday that moved Chelsea closer to a second consecutive Premier League title.
A 2-0 victory kept alive their slim hopes of regaining the Premier League title.
Liverpool manager Brendan Rodgers insists he is the right man for the job amid mounting pressure after a poor start to the season and a visit to in-form arch-rivals Manchester United on Sunday.
Manchester United completed a 3-0 aggregate win over AS Roma while Barcelona beat German side Schalke 04 by a single goal at home to secure a 2-0 aggregate victory in the quarter-final of the Champions League.
Champions Manchester United won the Community Shield 3-1 on penalties after a 0-0 draw against FA Cup winners Portsmouth at Wembley.
Following is a match by match look at the English Premier League's weekend fixtures
Mark Hughes was confirmed as Manchester City's new manager on Wednesday after quitting English Premier League rivals Blackburn Rovers. City's Web site said the 44-year-old Hughes, who signed a three-year deal, had agreed to join after meeting the club's new executive chairman Garry Cook on Tuesday.
Middlesbrough moved within two points of the top four with a 3-2 win over Manchester City in the English Premier League.
German international Mesut Ozil, who impressed one and all with his skills at the recently-concluded World Cup in South Africa, has become hot property. He is on the radar of top European clubs like Manchester United, Manchester City, Chelsea, Arsenal, Real Madrid and Barcelona.
Atletico Madrid tamed Lionel Messi and Neymar to send La Liga rivals Barcelona crashing out of the Champions League after Koke's early goal secured a shock 2-1 aggregate success at the Calderon on Wednesday.
Sergio Aguero proved he is still vital to Manchester City's cause as the Argentine paved the way for a routine 2-0 victory at bottom club Sunderland on Sunday.
Manchester United went top of the EPL after a 4-0 romp at Sunderland while Chelsea and Arsenal were held to a draw.
Juergen Klopp's side, chasing their maiden title in the Premier League era and first in the top flight in 30 years, took a 14th-minute lead from a Virgil van Dijk header but had to wait until stoppage time to put the game to bed through Mohamed Salah.
Between trying to compose himself, wiping away tears and facing a long standing ovation, it took Lionel Messi more than a minute to start his farewell news conference on Sunday at FC Barcelona, where the Argentine has spent all of his playing career.
Ivorian Drogba, who had been playing in the United States for Phoenix Rising, had two spells at Chelsea, scoring 164 goals in 381 games having spearheaded the west London club's revival under owner Roman Abramovich.
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